Article
The human complement component C1R gene: the exon-intron structure and the molecular basis of allelic diversity.
Annals of human genetics - 1 May 2003
Nakagawa M, Yuasa I, Irizawa Y, Umetsu K
Abstract excerpt
Human C1r is a component of the complement system, which is a major mediator of innate immunity. In this study we investigated the exon-intron organization of the human C1R gene, which spans 11 kb from the initiation codon to the stop codon, and is very similar in exon-intron structure to the C1S gene. Six common and rare alleles, C1R*1, C1R*2, C1R*5, C1R*8, C1R*9, and C1R*13, were characterized by five mutations...
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