Article
Major histocompatibility complex (MHC) complement deficiency, ancestral haplotypes and systemic lupus erythematosus (SLE): C4 deficiency explains some but not all of the influence of the MHC.
The Journal of rheumatology - 1 Sept 1991
Christiansen F T, Zhang W J, Griffiths M, Mallal S A, Dawkins R L
Abstract excerpt
In 1982 we reported that among Caucasians with systemic lupus erythematosus (SLE) there is an increased frequency of C4A null. As this allele occurs on the HLA-A1,B8,BfS, C4AQO,B1,DR3 (8.1) supratype, we suggested this accounted for the reported association of B8 and DR3. Since then we have shown...
Topics
- Alleles
- Australia
- Complement C2
- Complement C4
- Gene Frequency
- Haplotypes
- Humans
- Lupus Erythematosus, Systemic
- Major Histocompatibility Complex
- White People