Article
Genetic, structural and functional diversities of human complement components C4A and C4B and their mouse homologues, Slp and C4.
International immunopharmacology - 1 Mar 2001
Blanchong C A, Chung E K, Rupert K L, Yang Y, Yang Z, Zhou B, Moulds J M, Yu C Y
Abstract excerpt
The complement protein C4 is a non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. The covalent binding of C4 to immunoglobulins and immune complexes (IC) also enhances the solubilization of immune aggregates, and the clearance of IC through complement receptor one (CR1) on erythrocytes. Human C4 is the most polymorphic protein of the...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Blood Group Antigens
- Blood Proteins
- Complement C4
- Complement C4a
- Complement C4b
- DNA
- Gene Expression
- Genetic Variation
- Humans
- Mice
- Molecular Sequence Data