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Design of proteolytically stable RI-anchoring disruptor peptidomimetics for <i>in vivo</i> studies of anchored type I protein kinase A-mediated signalling

3 Sept 2009

Abstract excerpt

We have reported previously the design of a RIAD (RI-anchoring disruptor) peptide that specifically displaces PKA (protein kinase A) type I from the AKAP (A-kinase-anchoring protein) ezrin, which is present in the immunological synapse of T-cells. This increases immune reactivity by reducing the threshold for activation and may prove a feasible approach for improving immune function in patients with cAMP-mediated...

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PMID: 19715558
DOI: 10.1042/bj20090933

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