Article

Protease-Resistant Azapeptide GLP-1 Analogue Improves Metabolic Control in Diet-Induced Obesity

2025-05-14

Abstract excerpt

Peptide therapeutics are limited by rapid proteolysis and short half-lives. Azapeptides, created by replacing one or more α-carbon(s) on the peptide backbone with nitrogen atom(s), offer a strategy to improve peptide stability while preserving functional efficiency, yet their clinical potential has remained underexplored. Herein, we report the design, synthesis, in vitro and in vivo evaluations of azapeptide-bas...

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Literature Corpus work: 604e9b54-1196-5e5b-a974-ac3e04ebdc68
DOI: 10.1101/2025.05.09.653092

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