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Article

Structure of D-AKAP2:PKA RI complex: insights into AKAP specificity and selectivity.

Structure (London, England : 1993) - 10 Feb 2010

Sarma Ganapathy N, Kinderman Francis S, Kim Choel, von Daake Sventja, Chen Lirong, Wang Bi-Cheng, Taylor Susan S

Abstract excerpt

A-kinase anchoring proteins (AKAPs) regulate cyclic AMP-dependent protein kinase (PKA) signaling in space and time. Dual-specific AKAP 2 (D-AKAP2) binds to the dimerization/docking (D/D) domain of both RI and RII regulatory subunits of PKA with high affinity. Here we have determined the structures of the RIalpha D/D domain alone and in complex with D-AKAP2. The D/D domain presents an extensive surface for binding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20159461
DOI: 10.1016/j.str.2009.12.012
PMCID: PMC3090270

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