Article
Powerful bivariate genome-wide association analyses suggest the SOX6 gene influencing both obesity and osteoporosis phenotypes in males.
PloS one - 28 Aug 2009
Liu Yao-Zhong, Pei Yu-Fang, Liu Jian-Feng, Yang Fang, Guo Yan, Zhang Lei, Liu Xiao-Gang, Yan Han, Wang Liang, Zhang Yin-Ping, Levy Shawn, Recker Robert R, Deng Hong-Wen
Abstract excerpt
BACKGROUND: Current genome-wide association studies (GWAS) are normally implemented in a univariate framework and analyze different phenotypes in isolation. This univariate approach ignores the potential genetic correlation between important disease traits. Hence this approach is difficult to detect pleiotropic genes, which may exist for obesity and osteoporosis, two common diseases of major public health...
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