Article
BMD-associated variation at the Osterix locus is correlated with childhood obesity in females.
Obesity (Silver Spring, Md.) - 1 Jun 2011
Zhao Jianhua, Bradfield Jonathan P, Li Mingyao, Zhang Haitao, Mentch Frank D, Wang Kai, Sleiman Patrick M A, Kim Cecilia E, Glessner Joseph T, Frackelton Edward C, Chiavacci Rosetta M, Berkowitz Robert I, Zemel Babette S, Hakonarson Hakon, Grant Struan F A
Abstract excerpt
Recent genome wide association studies (GWAS) have revealed a number of genetic variants robustly associated with bone mineral density (BMD) and/or osteoporosis. Evidence from epidemiological and clinical studies has shown an association between BMD and BMI, presumably as a consequence of bone loading. We investigated the 23 previously published BMD GWAS-derived loci in the context of childhood obesity by...
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