Early life adversity promotes resilience to opioid addiction-related phenotypes in male rats and sex-specific transcriptional changes.

doi:10.1073/pnas.2020173118

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Article

Early life adversity promotes resilience to opioid addiction-related phenotypes in male rats and sex-specific transcriptional changes.

Proceedings of the National Academy of Sciences of the United States of America - 23 Feb 2021

Ordoñes Sanchez Evelyn, Bavley Charlotte C, Deutschmann Andre U, Carpenter Rachel, Peterson Drew R, Karbalaei Reza, Flowers James, Rogers Charleanne M, Langrehr Miranda G, Ardekani Cory S, Famularo Sydney T, Bongiovanni Angela R, Knouse Melissa C, Floresco Stan B, Briand Lisa A, Wimmer Mathieu E, Bangasser Debra A

Abstract excerpt

Experiencing some early life adversity can have an "inoculating" effect that promotes resilience in adulthood. However, the mechanisms underlying stress inoculation are unknown, and animal models are lacking. Here we used the limited bedding and nesting (LBN) model of adversity to evaluate stress inoculation of addiction-related phenotypes. In LBN, pups from postnatal days 2 to 9 and their dams were exposed to a...

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PMID: 33593913
DOI: 10.1073/pnas.2020173118
PMCID: PMC7923376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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