Article
A negative electrostatic determinant mediates the association between the Escherichia coli trp repressor and its operator DNA.
Protein science : a publication of the Protein Society - 1 Aug 1994
Guenot J, Fletterick R J, Kollman P A
Abstract excerpt
The electrostatic potential surfaces were characterized for trp repressor models that bind to DNA with sequence specificity, without specificity, and not at all. Comparisons among the surfaces were used to isolate protein surface features likely to be important in DNA binding. Models that differ in protein conformation and tryptophan-analogue binding consistently showed positive potential associated with the...
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