The basis for the super-repressor phenotypes of the AV77 and EK18 mutants of trp repressor.

doi:10.1006/jmbi.1999.3317

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Article

The basis for the super-repressor phenotypes of the AV77 and EK18 mutants of trp repressor.

Journal of molecular biology - 7 Jan 2000

Grillo A O, Royer C A

Abstract excerpt

The DNA-binding properties of two super-repressor mutants of the Escherichia coli trp repressor, EK18 and AV77, have been investigated using steady-state fluorescence anisotropy measurements, in order to further elucidate the basis for their super-repressor phenotypes. Several suggestions have been previously proposed as the basis for the super-repressor phenotype of EK18 and AV77. For the negative to positive...

Topics

Apoproteins
Bacterial Proteins
Base Sequence
Binding Sites
DNA
DNA-Binding Proteins
Dimerization
Escherichia coli
Fluorescein
Fluorescence Polarization
Models, Molecular
Mutation
Oligodeoxyribonucleotides
Operator Regions, Genetic
Operon
Phenotype
Repressor Proteins
Static Electricity

Source

Open in PubMed

Identifiers

PMID: 10623505
DOI: 10.1006/jmbi.1999.3317

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