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Article

Monitoring the T-Cell Receptor Repertoire at Single-Clone Resolution

20 Dec 2006

Abstract excerpt

The adaptive immune system recognizes billions of unique antigens using highly variable T-cell receptors. The alphabeta T-cell receptor repertoire includes an estimated 10(6) different rearranged beta chains per individual. This paper describes a novel micro-array based method that monitors the beta chain repertoire with a resolution of a single T-cell clone. These T-arrays are quantitative and detect T-cell...

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Share to Cytomegalovirus and herpesvirus research
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PMID: 17183685
DOI: 10.1371/journal.pone.0000055

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