Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epidermal-growth-factor-induced proliferation of astrocytes requires Egr transcription factors.

Journal of cell science - 15 Sept 2009

Mayer Sabine I, Rössler Oliver G, Endo Takeshi, Charnay Patrick, Thiel Gerald

Abstract excerpt

Stimulation of astrocytes with epidermal growth factor (EGF) induced proliferation and triggered the biosynthesis of the transcription factor Egr-1, involving the activation of the extracellular signal-regulated protein kinase (ERK) signaling pathway. No differences in the proliferation rate of astrocytes prepared from wild-type or Egr-1-deficient mice were detected. However, expression of a dominant-negative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activating Transcription Factor 2
Share to Early Growth Response Protein 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epidermal Growth Factor

Share to ets-Domain Protein Elk-1

Share to Extracellular Signal-Regulated MAP Kinases

Share to Fibroblast Growth Factor 2

Share to Mitogens

Share to Proto-Oncogene Proteins c-raf

Source

Identifiers

PMID: 19706684
DOI: 10.1242/jcs.048272

Genes

EGF
NAB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epidermal-growth-factor-induced proliferation of astrocytes requires Egr transcription factors.PMID 19706684Read ↗

A Positive Feed-forward Loop Associating EGR1 and PDGFA Promotes Proliferation and Self-renewal in Glioblastoma Stem CellsSemantic proximity Read ↗

EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial originSemantic proximity Read ↗

Activation of BAG3 by Egr-1 in response to FGF-2 in neuroblastoma cellsSemantic proximity Read ↗

The Neurogenic Potential of Astrocytes Is Regulated by Inflammatory Signals.Semantic proximity Read ↗

Inflammation Promotes a Conversion of Astrocytes into Neural Progenitor Cells via NF-κB Activation.Semantic proximity Read ↗

Phenotypic and gene expression modification with normal brain aging in GFAP-positive astrocytes and neural stem cells.Semantic proximity Read ↗

Nab proteins are essential for peripheral nervous system myelination.Semantic proximity Read ↗

EGR1 Upregulation during Encephalitic Viral Infections Contributes to Inflammation and Cell DeathSemantic proximity Read ↗

Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms.Semantic proximity Read ↗

The transcription factor early growth response 1 (Egr-1) advances differentiation of pre-B and immature B cells.Semantic proximity Read ↗

Establishment of an epidermal growth factor-dependent, multipotent neural precursor cell line.Semantic proximity Read ↗

HB-EGF and zinc activate EGFR to induce reactive neural stem cells in the mouse hippocampus after seizuresSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.