Article

HB-EGF and zinc activate EGFR to induce reactive neural stem cells in the mouse hippocampus after seizures

2022-11-03

Abstract excerpt

<h4>ABSTRACT</h4> Hippocampal seizures mimicking mesial temporal lobe epilepsy (MTLE) cause a profound disruption of the adult neurogenic niche in mice. Seizures provoke neural stem cells to switch to a reactive phenotype (reactive-neural stem cells, React-NSCs)) characterized by multibranched hypertrophic morphology, massive activation to enter mitosis, symmetric division and final differentiation into reactive...

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Literature Corpus work: 9594a695-76bd-5779-b79a-b96569a226ea
DOI: 10.1101/2022.11.02.514820

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