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Article

T cell receptor signaling co-regulates multiple Golgi genes to enhance N-glycan branching.

The Journal of biological chemistry - 20 Nov 2009

Chen Hung-Lin, Li Carey Fei, Grigorian Ani, Tian Wenqiang, Demetriou Michael

Abstract excerpt

T cell receptor (TCR) signaling enhances beta1,6GlcNAc-branching in N-glycans, a phenotype that promotes growth arrest and inhibits autoimmunity by increasing surface retention of cytotoxic T lymphocyte antigen-4 (CTLA-4) via interactions with galectins. N-Acetylglucosaminyltransferase V (MGAT5) mediates beta1,6GlcNAc-branching by transferring N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to N-glycan substrates...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19706602
DOI: 10.1074/jbc.M109.023630
PMCID: PMC2781660

Genes

MGAT1
MGAT5
MGAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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