Article
Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis.
Nature communications - 1 Jan 2011
Mkhikian Haik, Grigorian Ani, Li Carey F, Chen Hung-Lin, Newton Barbara, Zhou Raymond W, Beeton Christine, Torossian Sevan, Tatarian Gevork Grikor, Lee Sung-Uk, Lau Ken, Walker Erin, Siminovitch Katherine A, Chandy K George, Yu Zhaoxia, Dennis James W, Demetriou Michael
Abstract excerpt
How environmental factors combine with genetic risk at the molecular level to promote complex trait diseases such as multiple sclerosis (MS) is largely unknown. In mice, N-glycan branching by the Golgi enzymes Mgat1 and/or Mgat5 prevents T cell hyperactivity, cytotoxic T-lymphocyte antigen 4 (CTLA-4) endocytosis, spontaneous inflammatory demyelination and neurodegeneration, the latter pathologies characteristic...
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