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Article

Suppression of cancer progression by MGAT1 shRNA knockdown.

PloS one - 1 Jan 2012

Beheshti Zavareh Reza, Sukhai Mahadeo A, Hurren Rose, Gronda Marcela, Wang Xiaoming, Simpson Craig D, Maclean Neil, Zih Francis, Ketela Troy, Swallow Carol J, Moffat Jason, Rose David R, Schachter Harry, Schimmer Aaron D, Dennis James W

Abstract excerpt

Oncogenic signaling promotes tumor invasion and metastasis, in part, by increasing the expression of tri- and tetra- branched N-glycans. The branched N-glycans bind to galectins forming a multivalent lattice that enhances cell surface residency of growth factor receptors, and focal adhesion turno...

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Source

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Identifiers

PMID: 22957033
DOI: 10.1371/journal.pone.0043721
PMCID: PMC3434202

Genes

MGAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22957033-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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