Article
Activation of the transcriptional function of the NF-κB protein c-Rel by O-GlcNAc glycosylation.
Science signaling - 27 Aug 2013
Ramakrishnan Parameswaran, Clark Peter M, Mason Daniel E, Peters Eric C, Hsieh-Wilson Linda C, Baltimore David
Abstract excerpt
The transcription factor nuclear factor κB (NF-κB) rapidly reprograms gene expression in response to various stimuli, and its activity is regulated by several posttranslational modifications, including phosphorylation, methylation, and acetylation. The addition of O-linked β-N-acetylglucosamine (a process known as O-GlcNAcylation) is an abundant posttranslational modification that is enhanced in conditions such...
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