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Article

Activation of hematopoietic progenitor kinase 1 involves relocation, autophosphorylation, and transphosphorylation by protein kinase D1.

Molecular and cellular biology - 1 Mar 2005

Arnold Rüdiger, Patzak Irene M, Neuhaus Brit, Vancauwenbergh Sadia, Veillette André, Van Lint Johan, Kiefer Friedemann

Abstract excerpt

Adaptive immune signaling can be coupled to stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK) and NF-kappaB activation by the hematopoietic progenitor kinase 1 (HPK1), a mammalian hematopoiesis-specific Ste20 kinase. To gain insight into the regulation of leukocyte signal transduction, we investigated the molecular details of HPK1 activation. Here we demonstrate the capacity of the Src family...

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Identifiers

PMID: 15743830
DOI: 10.1128/MCB.25.6.2364-2383.2005
PMCID: PMC1061595

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activation of hematopoietic progenitor kinase 1 involves relocation, autophosphorylation, and transphosphorylation by protein kinase D1.PMID 15743830Read ↗

Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes.Semantic proximity Read ↗

Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase.Semantic proximity Read ↗

Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells.Semantic proximity Read ↗

HPK1 competes with ADAP for SLP‐76 binding and <i>via</i> Rap1 negatively affects T‐cell adhesionSemantic proximity Read ↗

SRC homology 2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) N-terminal tyrosine residues regulate a dynamic signaling equilibrium involving feedback of proximal T-cell receptor (TCR) signaling.Semantic proximity Read ↗

Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade.Semantic proximity Read ↗

A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function.Semantic proximity Read ↗

Activation or suppression of NFkappaB by HPK1 determines sensitivity to activation-induced cell death.Semantic proximity Read ↗

Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1.Semantic proximity Read ↗

T cell receptor-induced activation of phospholipase C-gamma1 depends on a sequence-independent function of the P-I region of SLP-76.Semantic proximity Read ↗

The adaptor protein Gads (Grb2-related adaptor downstream of Shc) is implicated in coupling hemopoietic progenitor kinase-1 to the activated TCR.Semantic proximity Read ↗

The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways.Semantic proximity Read ↗

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