Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase.

doi:10.1128/MCB.19.2.1359

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Article

Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase.

Molecular and cellular biology - 1 Feb 1999

Ling P, Yao Z, Meyer C F, Wang X S, Oehrl W, Feller S M, Tan T H

Abstract excerpt

Hematopoietic progenitor kinase 1 (HPK1), a mammalian Ste20-related protein kinase, is an upstream activator of c-Jun N-terminal kinase (JNK). In order to further characterize the HPK1-mediated JNK signaling cascade, we searched for HPK1-interacting proteins that could regulate HPK1. We found tha...

Topics

Adaptor Proteins, Signal Transducing
Amino Acid Sequence
Animals
COS Cells
Calcium-Calmodulin-Dependent Protein Kinases
Cell Line
Enzyme Activation
GRB2 Adaptor Protein
Humans
In Vitro Techniques
Interleukin-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

JNK Mitogen-Activated Protein Kinases

Jurkat Cells

Lymphocyte Activation

Mitogen-Activated Protein Kinases

Mutation

Nuclear Proteins

Protein Serine-Threonine Kinases

Source

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Identifiers

PMID: 9891069
DOI: 10.1128/MCB.19.2.1359
PMCID: PMC116064

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9891069-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase.PMID 9891069Read ↗

Activation of hematopoietic progenitor kinase 1 involves relocation, autophosphorylation, and transphosphorylation by protein kinase D1.Semantic proximity Read ↗

Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade.Semantic proximity Read ↗

A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1.Semantic proximity Read ↗

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Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1.Semantic proximity Read ↗

Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades.Semantic proximity Read ↗

Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells.Semantic proximity Read ↗

The adaptor protein Gads (Grb2-related adaptor downstream of Shc) is implicated in coupling hemopoietic progenitor kinase-1 to the activated TCR.Semantic proximity Read ↗

HPK1 competes with ADAP for SLP‐76 binding and <i>via</i> Rap1 negatively affects T‐cell adhesionSemantic proximity Read ↗

CrkIII: a novel and biologically distinct member of the Crk family of adaptor proteinsSemantic proximity Read ↗

SHP-1 protein tyrosine phosphatase associates with the adaptor protein CrkL.Semantic proximity Read ↗

Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase.Semantic proximity Read ↗

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