Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The human IgM pentamer is a mushroom-shaped molecule with a flexural bias.

Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 2009

Czajkowsky Daniel M, Shao Zhifeng

Abstract excerpt

The textbook planar model of pentameric IgM, a potent activator of complement C1q, is based upon the crystallographic structure of IgG. Although widely accepted, key predictions of this model have not yet been directly confirmed, which is particularly important since IgG lacks a major Ig fold domain in its Fc region that is present in IgM. Here, we construct a homology-based structural model of the IgM pentamer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Crystallography, X-Ray
Share to Immunoglobulin Fab Fragments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin M

Share to Microscopy, Atomic Force

Share to Protein Multimerization

Share to Protein Structure, Quaternary

Share to Sequence Homology, Amino Acid

Share to Structural Homology, Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 19706439
DOI: 10.1073/pnas.0903805106
PMCID: PMC2736442

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The human IgM pentamer is a mushroom-shaped molecule with a flexural bias.PMID 19706439Read ↗

Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamerSemantic proximity Read ↗

Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domainsSemantic proximity Read ↗

A Primer for Junior Trainees: The Structure, Binding, and Therapeutic Applications of Immunoglobulin GSemantic proximity Read ↗

Understanding IgM Structure and Biology to Engineer New Antibody TherapeuticsSemantic proximity Read ↗

Cryo-EM structure of the human IgM B cell receptorSemantic proximity Read ↗

Structural principles of B-cell antigen receptor assemblySemantic proximity Read ↗

Differences between Human and Mouse IgM Fc Receptor (FcµR).Semantic proximity Read ↗

IgG4 breaking the rulesSemantic proximity Read ↗

Existence of Different but Overlapping IgG- and IgM-Binding Sites on the Globular Domain of Human C1qSemantic proximity Read ↗

Emerging Functions of Natural IgM and Its Fc Receptor FCMR in Immune HomeostasisSemantic proximity Read ↗

Mutations in an avian IgY-Fc fragment reveal the locations of monocyte Fc receptor binding sites.Semantic proximity Read ↗

On-target IgG hexamerisation driven by a C-terminal IgM tail-piece fusion variant confers augmented complement activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.