Article
Differences between Human and Mouse IgM Fc Receptor (FcµR).
International journal of molecular sciences - 29 Jun 2021
Kubagawa Hiromi, Skopnik Christopher M, Al-Qaisi Khlowd, Calvert Rosaleen A, Honjo Kazuhito, Kubagawa Yoshiki, Teuber Ruth, Aliabadi Pedram Mahmoudi, Enghard Philipp, Radbruch Andreas, Sutton Brian J
Abstract excerpt
Both non-immune "natural" and antigen-induced "immune" IgM are important for protection against pathogens and for regulation of immune responses to self-antigens. Since the bona fide IgM Fc receptor (FcµR) was identified in humans by a functional cloning strategy in 2009, the roles of FcµR in these IgM effector functions have begun to be explored. In this short essay, we describe the differences between human and...
Topics
- Animals
- Apoptosis Regulatory Proteins
- Binding Sites
- Cloning, Molecular
- Humans
- Immunoglobulin M
- Ligands
- Membrane Proteins
- Mice
- Models, Molecular