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Article

Existence of Different but Overlapping IgG- and IgM-Binding Sites on the Globular Domain of Human C1q

1 Aug 2006

Abstract excerpt

C1q is the first subcomponent of the classical complement pathway that binds antigen-bound IgG or IgM and initiates complement activation via association of serine proteases C1r and C1s. The globular domain of C1q (gC1q), which is the ligand-recognition domain, is a heterotrimeric structure composed of the C-terminal regions of A (ghA), B (ghB), and C (ghC) chains. The expression and functional characterization...

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PMID: 16906756
DOI: 10.1021/bi060539v

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