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IgG4 breaking the rules

1 Jan 2002

Abstract excerpt

Immunoglobulin G4 (IgG4) antibodies have been known for some time to be functionally monovalent. Recently, the structural basis for this monovalency has been elucidated: the in vivo exchange of IgG half-molecules (one H-plus one L-chain) among IgG4. This process results in bispecific antibodies that in most situations will behave as functionally monovalent antibodies. The structural basis for the abnormal...

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PMID: 11849310
DOI: 10.1046/j.0019-2805.2001.01341.x

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