Article
On-target IgG hexamerisation driven by a C-terminal IgM tail-piece fusion variant confers augmented complement activation.
Communications biology - 2 Sept 2021
Sopp Joshua M, Peters Shirley J, Rowley Tania F, Oldham Robert J, James Sonya, Mockridge Ian, French Ruth R, Turner Alison, Beers Stephen A, Humphreys David P, Cragg Mark S
Abstract excerpt
The majority of depleting monoclonal antibody (mAb) drugs elicit responses via Fc-FcγR and Fc-C1q interactions. Optimal C1q interaction is achieved through hexameric Fc:Fc interactions at the target cell surface. Herein is described an approach to exploit the tailpiece of the naturally multimeric IgM to augment hexamerisation of IgG. Fusion of the C-terminal tailpiece of IgM promoted spontaneous hIgG hexamer...
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