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Article

Mutations in an avian IgY-Fc fragment reveal the locations of monocyte Fc receptor binding sites.

Developmental and comparative immunology - 1 Feb 2010

Taylor Alexander I, Sutton Brian J, Calvert Rosaleen A

Abstract excerpt

The avian IgY antibody isotype shares a common ancestor with both mammalian IgG and IgE and so provides a means to study the evolution of their structural and functional specialisations. Although both IgG and IgE bind to their leukocyte Fc receptors with 1:1 stoichiometry, IgY binds to CHIR-AB1, a receptor expressed in avian monocytes, with 2:1 stoichiometry. The mutagenesis data reported here explain the...

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Share to Avian Proteins
Share to Binding Sites
Share to Chickens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Fc Fragments

Share to Immunoglobulins

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Share to Protein Structure, Quaternary

Share to Receptors, Fc

Source

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Identifiers

PMID: 19733585
DOI: 10.1016/j.dci.2009.08.012
PMCID: PMC2795851

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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