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Article

Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo.

The Journal of biological chemistry - 9 Apr 2004

Kaiser Robert A, Bueno Orlando F, Lips Daniel J, Doevendans Pieter A, Jones Fred, Kimball Thomas F, Molkentin Jeffery D

Abstract excerpt

The p38 branch of the mitogen-activated protein kinase (MAPK) signaling cascade has been implicated as a regulator of cardiomyocyte apoptosis in culture as well as in the adult heart. However, considerable disagreement persists as to the functional effects attributed to p38 signaling, given that both pro- and anti-apoptotic regulatory roles have been reported. To address this area of uncertainty in the...

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Adenoviridae
Deoxyglucose
Immediate-Early Proteins
In Situ Nick-End Labeling
p38 Mitogen-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphoprotein Phosphatases

Protein Phosphatase 1

Reperfusion Injury

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PMID: 14749328
DOI: 10.1074/jbc.M313717200

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Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo.PMID 14749328Read ↗

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