Article
On dichotomizing phenotypes in family-based association tests: quantitative phenotypes are not always the optimal choice.
Genetic epidemiology - 1 Jul 2007
Fardo David, Celedón Juan C, Raby Benjamin A, Weiss Scott T, Lange Christoph
Abstract excerpt
In family-based association studies, quantitative traits are thought to provide higher statistical power than dichotomous traits. Consequently, it is standard practice to collect quantitative traits and to analyze them as such. However, in many situations, continuous measurements are more difficult to obtain and/or need to be adjusted for other factors/confounding variables which also have to be measured. In such...
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