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Article

A new powerful non-parametric two-stage approach for testing multiple phenotypes in family-based association studies.

Human heredity - 1 Jan 2003

Lange Christoph, Lyon Helen, DeMeo Dawn, Raby Benjamin, Silverman Edwin K, Weiss Scott T

Abstract excerpt

We introduce a new powerful nonparametric testing strategy for family-based association studies in which multiple quantitative traits are recorded and the phenotype with the strongest genetic component is not known prior to the analysis. In the first stage, using a population-based test based on the generalized estimating equation approach, we test all recorded phenotypes for association with the marker locus...

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Identifiers

PMID: 14614234
DOI: 10.1159/000073728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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