Article
Rapid high-throughput human leukocyte antigen typing by massively parallel pyrosequencing for high-resolution allele identification.
Human immunology - 1 Nov 2009
Gabriel Christian, Danzer Martin, Hackl Christa, Kopal Guido, Hufnagl Peter, Hofer Katja, Polin Helene, Stabentheiner Stephanie, Pröll Johannes
Abstract excerpt
Transplantation and, notably, hematopoietic stem cell transplantation require high-resolution human leukocyte antigen (HLA) typing and, because of the heterozygous genomic DNA samples, are dependent on clonal analytical methods. High-resolution HLA typing is a necessity for accomplishing the best possible histocompatibility match between donor and recipient, because mismatches strongly increase the risk of severe...
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