Article
Sequence capture and next generation resequencing of the MHC region highlights potential transplantation determinants in HLA identical haematopoietic stem cell transplantation.
DNA research : an international journal for rapid publication of reports on genes and genomes - 1 Aug 2011
Pröll Johannes, Danzer Martin, Stabentheiner Stephanie, Niklas Norbert, Hackl Christa, Hofer Katja, Atzmüller Sabine, Hufnagl Peter, Gülly Christian, Hauser Hanns, Krieger Otto, Gabriel Christian
Abstract excerpt
How cells coordinate the immune system activities is important for potentially life-saving organ or stem cell transplantations. Polymorphic immunoregulatory genes, many of them located in the human major histocompatibility complex, impact the process and assure the proper execution of tolerance-versus-activity mechanisms. In haematopoietic stem cell transplantation, on the basis of fully human leukocyte antigen...
Topics
- Epitopes
- Graft vs Host Disease
- HLA Antigens
- Hematopoietic Stem Cell Transplantation
- High-Throughput Nucleotide Sequencing
- Histocompatibility Testing
- Humans
- Polymorphism, Single Nucleotide