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Article

Reversal of Hox1 gene subfunctionalization in the mouse.

Developmental cell - 1 Aug 2006

Tvrdik Petr, Capecchi Mario R

Abstract excerpt

In vertebrates, paralogous Hox genes play diverse biological roles. We examined the interchangeability of Hoxa1 and Hoxb1 in mouse development by swapping their protein-coding regions. Remarkably, the mice expressing the Hox-B1 protein from the Hoxa1 locus, and vice versa, are essentially normal....

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Source

Identifiers

PMID: 16890163
DOI: 10.1016/j.devcel.2006.06.016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16890163-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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