Article
Disruption of Smad4 in odontoblasts causes multiple keratocystic odontogenic tumors and tooth malformation in mice.
Molecular and cellular biology - 1 Nov 2009
Gao Yuanrong, Yang Guan, Weng Tujun, Du Juan, Wang Xuejiu, Zhou Jian, Wang Songlin, Yang Xiao
Abstract excerpt
Keratocystic odontogenic tumors (KCOTs) are cystic epithelial neoplasias with a high recurrence rate. However, the molecular mechanisms underlying the initiation and progression of KCOTs are still largely unknown. Here, we show that specific ablation of Smad4 in odontoblasts unexpectedly resulted in spontaneous KCOTs in mice. The mutant mice exhibited malformed teeth characterized by fractured incisors and...
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