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Article

Molecular alterations in odontogenic keratocysts as potential therapeutic targets.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Nov 2017

Gomes Carolina Cavalieri, Guimarães Letícia Martins, Diniz Marina Gonçalves, Gomez Ricardo Santiago

Abstract excerpt

The odontogenic keratocyst (OKC) is a cystic lesion, lined by uniformly thickened parakeratinized epithelium. Some lesions are large and tend to recur after surgical treatment. The neoplastic nature of OKCs remains a matter of dispute. It is known that some sporadic OKCs harbor PTCH1 mutations, and via the dissection of cyst epithelium, these mutations were demonstrated to occur much more frequently than...

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Identifiers

PMID: 28489259
DOI: 10.1111/jop.12591

Genes

PTCH1

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