Article
Oncogenic signalling pathways in benign odontogenic cysts and tumours.
Oral oncology - 1 Sept 2017
Diniz Marina Gonçalves, Gomes Carolina Cavalieri, de Sousa Sílvia Ferreira, Xavier Guilherme Machado, Gomez Ricardo Santiago
Abstract excerpt
The first step towards the prevention of cancer is to develop an in-depth understanding of tumourigenesis and the molecular basis of malignant transformation. What drives tumour initiation? Why do most benign tumours fail to metastasize? Oncogenic mutations, previously considered to be the hallmark drivers of cancers, are reported in benign cysts and tumours, including those that have an odontogenic origin....
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