Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Roles of Bmp4 during tooth morphogenesis and sequential tooth formation.

Development (Cambridge, England) - 15 Jan 2013

Jia Shihai, Zhou Jing, Gao Yang, Baek Jin-A, Martin James F, Lan Yu, Jiang Rulang

Abstract excerpt

Previous studies have suggested that Bmp4 is a key Msx1-dependent mesenchymal odontogenic signal for driving tooth morphogenesis through the bud-to-cap transition. Whereas all tooth germs were arrested at the bud stage in Msx1(-/-) mice, we show that depleting functional Bmp4 mRNAs in the tooth mesenchyme, through neural crest-specific gene inactivation in Bmp4(f/f);Wnt1Cre mice, caused mandibular molar...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Protein 4
Share to Intercellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Microscopy, Fluorescence

Share to Morphogenesis

Share to MSX1 Transcription Factor

Share to Odontogenesis

Share to Zinc Fingers

Source

Open in PubMed Open full text

Identifiers

PMID: 23250216
DOI: 10.1242/dev.081927
PMCID: PMC3597212

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Roles of Bmp4 during tooth morphogenesis and sequential tooth formation.PMID 23250216Read ↗

MSX1 Drives Tooth Morphogenesis Through Controlling Wnt Signaling ActivitySemantic proximity Read ↗

Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row.Semantic proximity Read ↗

Transgenically ectopic expression of Bmp4 to the Msx1 mutant dental mesenchyme restores downstream gene expression but represses Shh and Bmp2 in the enamel knot of wild type tooth germ.Semantic proximity Read ↗

Msx1 controls inductive signaling in mammalian tooth morphogenesis.Semantic proximity Read ↗

Different Roles of Runx2 During Early Neural Crest–Derived Bone and Tooth DevelopmentSemantic proximity Read ↗

Control of tooth morphogenesis by Runx2.Semantic proximity Read ↗

Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19(INK4d) expression during odontogenesis.Semantic proximity Read ↗

Integrated Genetic Networks and Epigenetic Regulation in Tooth Development and MaturationSemantic proximity Read ↗

Noggin is required for early development of murine upper incisors.Semantic proximity Read ↗

Dentinogenesis and Tooth-Alveolar Bone Complex Defects in BMP9/GDF2 Knockout MiceSemantic proximity Read ↗

Disruption of Smad4 in odontoblasts causes multiple keratocystic odontogenic tumors and tooth malformation in mice.Semantic proximity Read ↗

Msx2 -/- transgenic mice develop compound amelogenesis imperfecta, dentinogenesis imperfecta and periodental osteopetrosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.