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Article

The Role of Extracellular DNA in Autoimmunity in SLE

23 Jun 2009

Abstract excerpt

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the expression of antibodies to DNA. These antibodies form immune complexes that can stimulate cytokine production as well as deposit in the tissues to incite inflammation and damage. For the formation of immune complexes, the availability of extracellular DNA in an immunologically relevant form is essential. While apoptosis...

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PMID: 19703007
DOI: 10.1111/j.1365-3083.2009.02300.x

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