Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Systemic Lupus Erythematosus and DNA Degradation and Elimination Defects

7 Aug 2019

Abstract excerpt

The pathogenesis of Systemic Lupus Erythematosus (SLE) remains unclear, with numerous studies pointing to a combination of genetic and environmental factors. A critical stage in SLE disease development is cell necrosis, in which undegraded chromatin and nucleoproteins are released into the blood, resulting in circulating cell-free DNA and serum nucleoproteins that trigger anti-dsDNA autoantibody production. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Cell Function and Interaction
Share to Systemic Lupus Erythematosus Research
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31440232
DOI: 10.3389/fimmu.2019.01697

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systemic Lupus Erythematosus and DNA Degradation and Elimination DefectsPMID 31440232Read ↗

Self-DNA at the Epicenter of SLE: Immunogenic Forms, Regulation, and EffectsSemantic proximity Read ↗

The central role of nucleic acids in the pathogenesis of systemic lupus erythematosusSemantic proximity Read ↗

DNA Damage and Deficiencies in the Mechanisms of Its Repair: Implications in the Pathogenesis of Systemic Lupus ErythematosusSemantic proximity Read ↗

The dsDNA, Anti-dsDNA Antibody, and Lupus Nephritis: What We Agree on, What Must Be Done, and What the Best Strategy Forward Could BeSemantic proximity Read ↗

The Real Culprit in Systemic Lupus Erythematosus: Abnormal Epigenetic RegulationSemantic proximity Read ↗

An Emerging Role for Anti-DNA Antibodies in Systemic Lupus ErythematosusSemantic proximity Read ↗

Pathogenesis and potential therapeutic targets in systemic lupus erythematosus: from bench to bedsideSemantic proximity Read ↗

Systemic Lupus ErythematosusSemantic proximity Read ↗

New insights into the immunopathogenesis of systemic lupus erythematosus.Semantic proximity Read ↗

The Role of Extracellular DNA in Autoimmunity in SLESemantic proximity Read ↗

Monogenic systemic lupus erythematosus: insights in pathophysiology.Semantic proximity Read ↗

Contribution of impaired DNASE1L3 activity to anti-DNA autoantibody production in systemic lupus erythematosusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.