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Article

Triggers for anti-chromatin autoantibody production in SLE

1 Dec 2002

Abstract excerpt

The formation of autoantibodies against chromatin is the main feature of systemic lupus erythematosis (SLE), an autoimmune disease, which is T-cell dependent and autoantigen-driven. Historically, antibodies against dsDNA, one of the components of chromatin, are considered as a hallmark of SLE. However, dsDNA is poorly immunogenic. Nucleosome-specific T helper cells have been identified. These T cells propagate...

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PMID: 12529051
DOI: 10.1191/0961203302lu307rr

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