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Article

The Role of Cell Death in the Pathogenesis of SLE : Is Pyroptosis the Missing Link?

27 Jun 2015

Abstract excerpt

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the production of antinuclear antibodies (ANAs) in association with systemic inflammation and organ damage. In addition to genetic factors, a contribution of infection to disease induction has been proposed. In the pathogenesis of lupus, immune complexes of ANAs with nuclear antigens can form and both deposit in the tissue and...

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PMID: 26118732
DOI: 10.1111/sji.12335

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