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Article

Specific short transmembrane sequences can inhibit transformation by the mutant neu growth factor receptor in vitro and in vivo.

Oncogene - 1 Oct 1993

Lofts F J, Hurst H C, Sternberg M J, Gullick W J

Abstract excerpt

The neu oncogene is activated by a point mutation within its transmembrane domain that results in the substitution of glutamic acid for valine at position 664, and is associated with constitutive activation of the tyrosine kinase. It has been proposed that the mutation allows for stabilization of homodimers of the receptor that are necessary for transduction of the mitogenic signal. To investigate the role of the...

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PMID: 8104327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Specific short transmembrane sequences can inhibit transformation by the mutant neu growth factor receptor in vitro and in vivo.PMID 8104327Read ↗

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Characterization of the proto-oncogenic and mutant forms of the transmembrane region of Neu in micelles.Semantic proximity Read ↗

Agonistic antibodies stimulate the kinase encoded by the neu protooncogene in living cells but the oncogenic mutant is constitutively active.Semantic proximity Read ↗

Mutation of the salt bridge-forming residues in the ETV6-SAM domain interface blocks ETV6-NTRK3-induced cellular transformation.Semantic proximity Read ↗

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