Article
Specific short transmembrane sequences can inhibit transformation by the mutant neu growth factor receptor in vitro and in vivo.
Oncogene - 1 Oct 1993
Lofts F J, Hurst H C, Sternberg M J, Gullick W J
Abstract excerpt
The neu oncogene is activated by a point mutation within its transmembrane domain that results in the substitution of glutamic acid for valine at position 664, and is associated with constitutive activation of the tyrosine kinase. It has been proposed that the mutation allows for stabilization of...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Base Sequence
- Cell Division
- Cell Membrane
- Cell Transformation, Neoplastic
- Down-Regulation
- Mice
- Mice, Nude
- Molecular Sequence Data
- Mutation
- Neoplasm Transplantation
- Proto-Oncogene Proteins
- Receptor, ErbB-2
- Structure-Activity Relationship