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Article

p38α and p38γ Mediate Oncogenic ras-induced Senescence through Differential Mechanisms

28 Feb 2009

Abstract excerpt

Oncogene-induced senescence is a tumor-suppressive defense mechanism triggered upon activation of certain oncogenes in normal cells. Recently, the senescence response to oncogene activation has been shown to act as a bona fide barrier to cancer development in vivo. Multiple previous studies have implicated the importance of the p38 MAPK pathway in oncogene-induced senescence. However, the contribution of each of...

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Share to Advanced biosensing and bioanalysis techniques
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Share to Telomeres, Telomerase, and Senescence

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PMID: 19251701
DOI: 10.1074/jbc.m808327200

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