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Article

Stepwise up‐regulation of MicroRNA expression levels from replicating to reversible and irreversible growth arrest states in WI‐38 human fibroblasts

27 May 2009

Abstract excerpt

MicroRNAs (miRNAs) are small non-coding RNAs that regulate diverse genetic expression networks through their control of mRNA stability or translation. Their role in aging mechanisms has been proposed in various model systems. In this report, the expression profiling of 462 human miRNAs in the reversible growth arrest state of quiescence, and irreversible states of replicative senescence and hydrogen...

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PMID: 19475566
DOI: 10.1002/jcp.21834

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