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p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes

14 Nov 2013

Abstract excerpt

Cellular senescence contributes to aging and decline in tissue function. p53 isoform switching regulates replicative senescence in cultured fibroblasts and is associated with tumor progression. Here, we found that the endogenous p53 isoforms Δ133p53 and p53β are physiological regulators of proliferation and senescence in human T lymphocytes in vivo. Peripheral blood CD8+ T lymphocytes collected from healthy...

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PMID: 24231352
DOI: 10.1172/jci70355

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