Mitomycin C cross-resistance induced by adriamycin in human ovarian cancer cells in vitro.

doi:10.1007/BF02897288

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Mitomycin C cross-resistance induced by adriamycin in human ovarian cancer cells in vitro.

Cancer chemotherapy and pharmacology - 1 Jan 1990

Mizuno K, Furuhashi Y, Maeda O, Iwata M, Misawa T, Kawai M, Kano T, Tomoda Y

Abstract excerpt

We prepared Adriamycin-resistant cancer cells by exposing an ovarian serous cystadenocarcinoma cell line to the drug. The resistant cells also showed cross-resistance to a wide variety of other compounds, including vincristine, vinblastine, actinomycin D, daunorubicin, mitomycin C and carboquone. Against vincristine, the cells showed a greater than 5,000-fold increase in resistance, far surpassing their...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Cyclosporins
Cystadenocarcinoma
DNA, Neoplasm
Doxorubicin
Drug Resistance
Female
Humans
Membrane Glycoproteins
Mitomycin
Mitomycins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovarian Neoplasms

Phenotype

RNA, Messenger

RNA, Neoplasm

Tumor Cells, Cultured

Verapamil

Vincristine

Source

Open in PubMed

Identifiers

PMID: 1976451
DOI: 10.1007/BF02897288

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1976451-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitomycin C cross-resistance induced by adriamycin in human ovarian cancer cells in vitro.PMID 1976451Read ↗

Drug ResistanceSemantic proximity Read ↗

Multiple drug-resistance in variant of a human non-small cell lung carcinoma cell line, DLKP-A.Semantic proximity Read ↗

Acquired resistance to gemcitabine and cross-resistance in human pancreatic cancer clonesSemantic proximity Read ↗

Induction of resistance to 2',2'-difluorodeoxycytidine in the human ovarian cancer cell line A2780.Semantic proximity Read ↗

Identification of mutations at DNA topoisomerase I responsible for camptothecin resistance.Semantic proximity Read ↗

Sensitivity of drug-resistant human ovarian tumor cell lines to combined effects of tumor necrosis factor (TNF-alpha) and doxorubicin: failure of the combination to modulate the MDR phenotype.Semantic proximity Read ↗

Multidrug resistance in tumour cells: characterization of the multidrug resistant cell line K562-Lucena 1.Semantic proximity Read ↗

Biological characterization of multidrug-resistant human colon carcinoma sublines induced/selected by two methods.Semantic proximity Read ↗

Pleiotropic-resistant phenotype is a multifactorial phenomenon in human colon carcinoma cell lines.Semantic proximity Read ↗

Multidrug resistance phenotype in the RMS-GR human rhabdomyosarcoma cell line obtained after polychemotherapy.Semantic proximity Read ↗

Establishment of cisplatin-resistant variants of human neuroblastoma cell lines, TGW and GOTO, and their drug cross-resistance profiles.Semantic proximity Read ↗

Therapeutic differentiation in a human rhabdomyosarcoma cell line selected for resistance to actinomycin D.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.