Article
Inhibition of N-linked glycosylation of P-glycoprotein by tunicamycin results in a reduced multidrug resistance phenotype.
British journal of cancer - 1 Apr 1995
Kramer R, Weber T K, Arceci R, Ramchurren N, Kastrinakis W V, Steele G, Summerhayes I C
Abstract excerpt
Characterisation of altered glycosylation of P-glycoprotein (P-gp) found associated with the absence of a multidrug resistance (MDR) phenotype in cell lines prompted an investigation to assess the role of post-translational processing in establishing P-gp efflux pump functionally. The clone A cell line used in this study displays a strong MDR phenotype mediated by high constitutive levels of expression of P-gp....
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Blotting, Western
- Cell Line
- Cell Membrane
- Colorectal Neoplasms
- Drug Resistance, Multiple
- ErbB Receptors
- Flow Cytometry
- Glycosylation
- Humans