Article
Interspecies trait genetics reveals association of Adcy8 with mouse avoidance behavior and a human mood disorder.
Biological psychiatry - 15 Dec 2009
de Mooij-van Malsen Annetrude J G, van Lith Hein A, Oppelaar Hugo, Hendriks Judith, de Wit Marina, Kostrzewa Elzbieta, Breen Gerome, Collier David A, Olivier Berend, Kas Martien J
Abstract excerpt
BACKGROUND: Identifying susceptibility genes for endophenotypes by studying analogous behaviors across species is an important strategy for understanding the pathophysiology underlying psychiatric disorders. This approach provides novel biological pathways plus validated animal models critical for selective drug development. One such endophenotype is avoidance behavior. METHODS: In the present study, novel...
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