Article
An association analysis of murine anxiety genes in humans implicates novel candidate genes for anxiety disorders.
Biological psychiatry - 15 Oct 2008
Donner Jonas, Pirkola Sami, Silander Kaisa, Kananen Laura, Terwilliger Joseph D, Lönnqvist Jouko, Peltonen Leena, Hovatta Iiris
Abstract excerpt
BACKGROUND: Human anxiety disorders are complex diseases with largely unknown etiology. We have taken a cross-species approach to identify genes that regulate anxiety-like behavior with inbred mouse strains that differ in their innate anxiety levels as a model. We previously identified 17 genes with expression levels that correlate with anxiety behavior across the studied strains. In the present study, we tested...
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