Estrogen-Dependent Upregulation of Adcyap1r1 Expression in Nucleus Accumbens Is Associated With Genetic Predisposition of Sex-Specific QTL for Alcohol Consumption on Rat Chromosome 4

Abstract excerpt

Humans show sex differences related to alcohol use disorders. Animal model research has the potential to provide important insight into how sex differences affect alcohol consumption, particularly because female animals frequently drink more than males. In previous work, inbred strains of the selectively-bred alcohol-preferring (P) and nonpreferring (NP) rat lines revealed a highly significant quantitative trait...

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