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Article

Antiherpetic properties of acyclovir 5'-hydrogenphosphonate and the mutation analysis of herpes virus resistant strains.

Chemical biology & drug design - 1 Oct 2009

Gus'kova Anna A, Skoblov Mikhail Yu, Korovina Anna N, Yasko Maxim V, Karpenko Inna L, Kukhanova Marina K, Andronova Valeria L, Galegov George A, Skoblov Yuri S

Abstract excerpt

In this study, we continued to study antiherpetic properties of acyclovir 5'-hydrogenphosphonate (Hp-ACV) in cell cultures and animal models. Hp-ACV was shown to inhibit the development of herpetic infection in mice induced by the HSV-1/L(2) strain. The compound suppressed replication of both ACV-sensitive HSV-1/L(2) and ACV-resistant HSV-1/L(2)/R strains in Vero cell culture. Viral population resistant to Hp-ACV...

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PMID: 19691467
DOI: 10.1111/j.1747-0285.2009.00874.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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