Article
Antiherpetic properties of acyclovir 5'-hydrogenphosphonate and the mutation analysis of herpes virus resistant strains.
Chemical biology & drug design - 1 Oct 2009
Gus'kova Anna A, Skoblov Mikhail Yu, Korovina Anna N, Yasko Maxim V, Karpenko Inna L, Kukhanova Marina K, Andronova Valeria L, Galegov George A, Skoblov Yuri S
Abstract excerpt
In this study, we continued to study antiherpetic properties of acyclovir 5'-hydrogenphosphonate (Hp-ACV) in cell cultures and animal models. Hp-ACV was shown to inhibit the development of herpetic infection in mice induced by the HSV-1/L(2) strain. The compound suppressed replication of both ACV-sensitive HSV-1/L(2) and ACV-resistant HSV-1/L(2)/R strains in Vero cell culture. Viral population resistant to Hp-ACV...
Topics
- Acyclovir
- Amino Acid Sequence
- Animals
- Antiviral Agents
- Chlorocebus aethiops
- Drug Resistance, Viral
- Herpesviridae
- Herpesviridae Infections
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Mutation
- Sequence Alignment